Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.52 |
| ▸ | F10 | P00742 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358089 | 0.88 | CCR2 (0.50) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6999936 | 0.85 | CCR2 (0.56) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6300925 | 0.85 | CCR2 (0.71) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6358220 | 0.83 | MEN1 (0.51) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL7000014 | 0.83 | CCR2 (0.56) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6302602 | 0.82 | CCR2 (0.57) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6306975 | 0.82 | CCR2 (0.72) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6596933 | 0.82 | CCR2 (0.57) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL6303484 | 0.82 | CCR2 (0.72) | CCR2F10MAPTLMNAGAA | |
| SCHEMBL7855473 | 0.82 | CCR2 (0.54) | CCR2F10MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6911465-B1 | Anti-inflammatory indole derivatives | ASTRAZENECA AB (SE) | 2005-06-28 | — | — | US | disclosed |
| US-20050026975-A1 | Anti-inflammatory indole derivatives | ASTRAZENECA AB (SE) | 2005-02-03 | — | — | US | disclosed |
| EP-1159269-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| EP-1159269-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000046195-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026975-A1 | Anti-inflammatory indole derivatives | CCR5, CCR2, CCL5 | CCR2 2/4885F10 4214/4885MAPT 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.