Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226781 | 0.85 | MAPT (0.44) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7645771 | 0.84 | MAPT (0.43) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7646167 | 0.82 | MAPT (0.43) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6935668 | 0.79 | MAPT (0.44) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7000840 | 0.76 | MAPT (0.41) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7441422 | 0.76 | MDM2 (0.41) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL7227511 | 0.76 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL7002338 | 0.75 | MAPT (0.41) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6933786 | 0.72 | PSD (0.44) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7235436 | 0.72 | MAPT (0.47) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001956-B1 | 2,3-BENZODIAZEPINE DERIVATIVES | GYOGYSZERKUTATO INTEZET (HU) | 2003-05-07 | — | — | EP | disclosed |
| US-6482819-B1 | 2,3-benzodiazepine derivatives | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2002-11-19 | — | — | US | disclosed |
| EP-1001956-A1 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006408-A1 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | Gyógyszerkutató Intézet Kft. (HU) | 1999-02-11 | — | — | WO | disclosed |