Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999879 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2GAATDP1SIRT6RAB9A | |
| SCHEMBL2060778 | 0.92 | TDP1 (0.47) | SMN1; SMN2GAATDP1SIRT6RAB9A | |
| SCHEMBL8113298 | 0.86 | HSD17B1 (0.37) | SMN1; SMN2GAATDP1SIRT6RAB9A | |
| SCHEMBL2241521 | 0.82 | GAA (0.61) | SMN1; SMN2GAATDP1LMNAMAPT | |
| SCHEMBL2060925 | 0.80 | MEN1 (0.43) | SMN1; SMN2GAATDP1SIRT6RAB9A | |
| SCHEMBL2061774 | 0.80 | GAA (0.50) | SMN1; SMN2GAATDP1SIRT6RAB9A | |
| SCHEMBL2062089 | 0.78 | HTR2A (0.54) | TDP1SIRT6RAB9AALDH1A1LMNA | |
| SCHEMBL2574136 | 0.78 | SIRT6 (0.57) | SMN1; SMN2GAATDP1SIRT6RAB9A | |
| SCHEMBL7002049 | 0.77 | TDP1 (0.44) | TDP1SIRT6RAB9AALDH1A1LMNA | |
| SCHEMBL7000772 | 0.77 | TDP1 (0.44) | TDP1SIRT6ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |