Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859486 | 0.76 | HTT (0.40) | CXCR2CXCR1HTTALDH1A1MAPK1 | |
| SCHEMBL6859513 | 0.72 | CXCR2 (0.65) | CXCR2CXCR1SMN1; SMN2SCN9ASCN5A | |
| SCHEMBL4227284 | 0.65 | MAPT (0.45) | CXCR2HTTALDH1A1MAPK1MAPT | |
| SCHEMBL6864235 | 0.63 | CXCR2 (0.48) | CXCR2CXCR1SMN1; SMN2SCN9ASCN5A | |
| SCHEMBL6866177 | 0.61 | CXCR2 (0.46) | CXCR2HTTALDH1A1MAPTLMNA | |
| SCHEMBL11880674 | 0.58 | ALDH1A1 (0.47) | HTTALDH1A1MAPTLMNANPC1 | |
| SCHEMBL6866004 | 0.57 | CXCR2 (0.65) | CXCR2CXCR1ALDH1A1SMN1; SMN2SCN9A | |
| SCHEMBL1787273 | 0.57 | ALDH1A1 (0.39) | HTTALDH1A1MAPK1MAPTLMNA | |
| SCHEMBL5014492 | 0.56 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNATP53HPGD | |
| SCHEMBL19216330 | 0.56 | RAB9A (0.71) | HTTALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |