Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 16/20 | 0.47 |
| ▸ | HTR1B | P28222 | 15/20 | 0.47 |
| ▸ | HTR1A | P08908 | 7/20 | 0.47 |
| ▸ | HTR1F | P30939 | 6/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999514 | 0.83 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL6991172 | 0.80 | HTR1D (0.48) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL8128883 | 0.74 | HTR1A (0.64) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL6999186 | 0.72 | HTR1D (0.58) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL6992924 | 0.72 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL8130310 | 0.71 | HTR1A (0.44) | HTR1DHTR1BHTR1AMAPT | |
| SCHEMBL6999683 | 0.71 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL6993724 | 0.70 | HTR1D (0.44) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL7000915 | 0.70 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL6992985 | 0.69 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR1FCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | claimed |
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | disclosed |
| US-6391891-B1 | ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | SMITHKLINE BEECHAM PLC (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-1003738-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007700-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-18 | — | — | WO | disclosed |