Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24081206 | 0.87 | NFKB1 (0.54) | NFKB1L3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL20411973 | 0.85 | NFKB1 (0.53) | HTR2ANFKB1L3MBTL1MAPTKDM4E | |
| SCHEMBL6562985 | 0.85 | HRH1 (0.48) | HTR2AL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL8541432 | 0.84 | NFKB1 (0.44) | HTR2ANFKB1L3MBTL1MAPTKDM4E | |
| SCHEMBL23531409 | 0.84 | RAB9A (0.54) | HTR2ANFKB1L3MBTL1MAPTKDM4E | |
| SCHEMBL11627706 | 0.83 | HRH3 (0.56) | HTR2AL3MBTL1KDM4ECYP1A2TDP1 | |
| SCHEMBL21339921 | 0.83 | NFKB1 (0.50) | NFKB1L3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL5712637 | 0.83 | RAB9A (0.53) | HTR2ANFKB1L3MBTL1MAPTKDM4E | |
| SCHEMBL2619347 | 0.83 | NFKB1 (0.54) | NFKB1L3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL10484107 | 0.82 | NFKB1 (0.44) | HTR2ANFKB1L3MBTL1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |