Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | XBP1 | P17861 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24660448 | 0.90 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL5960981 | 0.87 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL7222255 | 0.87 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL15875342 | 0.84 | TDP1 (0.55) | LMNATSHRSMN1; SMN2TP53S1PR4 | |
| SCHEMBL29485563 | 0.83 | TDP1 (0.61) | KMT2ASMN1; SMN2TP53MAPTTDP1 | |
| SCHEMBL21062722 | 0.83 | LMNA (0.43) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL21062719 | 0.83 | LMNA (0.43) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL29161752 | 0.82 | LMNA (0.42) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL29161751 | 0.82 | LMNA (0.42) | ALDH1A1LMNAHPGDHTTNPSR1 | |
| SCHEMBL1610078 | 0.82 | TDP1 (0.48) | LMNATSHRS1PR4TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317459-A1 | BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS | AstraZeneca AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020530-A1 | BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-03-14 | — | — | WO | disclosed |