SCHEMBL7002

SCHEMBL7002

Cc1noc(-c2ccc(Br)cc2)c1COC(=O)NCCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 7/20 0.48
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
LPAR1 Q92633 1/20 0.41
TSHR P16473 1/20 0.40
FAAH O00519 1/20 0.40
MMP1 P03956 1/20 0.40
MMP2 P08253 1/20 0.40
MMP3 P08254 1/20 0.40
MMP7 P09237 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6821 0.90 AKR1C3 (0.46) AKR1C3LPAR1ALDH1A1
SCHEMBL6491 0.85 LPAR1 (0.53) AKR1C3LPAR1MMP1MMP2MMP3
SCHEMBL7106 0.84 P2RX7 (0.46) AKR1C3TSHRFAAHPLAAT3PLAAT5
SCHEMBL7158 0.80 TSHR (0.58) AKR1C3TSHRFAAHL3MBTL1MAPT
SCHEMBL18597680 0.80 ALDH1A1 (0.50) LPAR1TSHRL3MBTL1ALDH1A1
SCHEMBL5869 0.80 ALDH1A1 (0.50) LPAR1TSHRL3MBTL1ALDH1A1
SCHEMBL7013 0.80 ALDH1A1 (0.50) LPAR1TSHRL3MBTL1ALDH1A1
SCHEMBL1347 0.78 KMT2A (0.43) AKR1C3HDAC1TSHRMAPT
SCHEMBL2072 0.78 ALDH1A1 (0.46) AKR1C3LPAR1TSHRL3MBTL1ALDH1A1
SCHEMBL343051 0.77 LPAR1 (0.56) LPAR1TSHRALDH1A1MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed