Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.45 |
| ▸ | CTSL | P07711 | 4/20 | 0.40 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065886 | 0.92 | CTSS (0.46) | CTSSCTSLCTSBCTSKNOTUM | |
| SCHEMBL3807046 | 0.85 | CTSS (0.40) | CTSSCTSLCTSBCTSKNOTUM | |
| SCHEMBL3060577 | 0.85 | CTSS (0.40) | CTSSCTSLCTSBCTSKNOTUM | |
| SCHEMBL3073598 | 0.85 | CTSS (0.58) | CTSS | |
| SCHEMBL700379 | 0.84 | CTSS (0.67) | CTSSCTSLCTSB | |
| SCHEMBL3065798 | 0.81 | CTSL (0.59) | CTSSCTSLCTSBCTSK | |
| SCHEMBL698949 | 0.80 | CTSS (0.46) | CTSSCTSLCTSB | |
| SCHEMBL3073773 | 0.78 | DPP4 (0.40) | CTSSNOTUMHSD11B1LMNAMEN1 | |
| Lithium Ion SCHEMBL2106607 | 0.78 | CTSS (0.42) | CTSSCTSLCTSBCTSKHSD11B1 | |
| SCHEMBL2102652 | 0.78 | NR1H2 (0.47) | CTSSCTSLCTSBCTSKHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |