Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1526690 | 0.88 | GPR84 (0.46) | GAAALDH1A1CYP1A2KMT2ACYP2C9 | |
| SCHEMBL1526691 | 0.88 | GPR84 (0.46) | GAAALDH1A1CYP1A2KMT2ACYP2C9 | |
| SCHEMBL20801025 | 0.85 | GAA (0.69) | GAAALDH1A1CYP1A2KMT2ACYP2C9 | |
| SCHEMBL7475825 | 0.83 | CYP1A2 (0.62) | GAAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31588461 | 0.83 | CYP1A2 (0.62) | GAAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7529280 | 0.83 | CYP1A2 (0.62) | GAAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4869131 | 0.82 | CYP1A2 (0.57) | GAAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31712158 | 0.81 | GAA (0.50) | GAAALDH1A1CYP1A2KMT2ACYP2C9 | |
| SCHEMBL4860312 | 0.79 | ALDH1A1 (0.45) | GAAALDH1A1CYP1A2KMT2ACYP2C9 | |
| SCHEMBL6845476 | 0.79 | ALDH1A1 (0.45) | GAAALDH1A1CYP1A2KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123936-B1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-12-10 | — | — | EP | disclosed |
| US-6627630-B1 | Preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria prurigo and antiallergins | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |