Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002157 | 0.93 | ALDH1A1 (0.35) | P2RY14ALDH1A1PTGER4MEN1KMT2A | |
| SCHEMBL331277 | 0.90 | CNR2 (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2CNR1 | |
| SCHEMBL332202 | 0.82 | MEN1 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL7002042 | 0.81 | LMNA (0.39) | P2RY14ALDH1A1PTGER4MEN1KMT2A | |
| SCHEMBL331632 | 0.80 | SMN1; SMN2 (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2CNR1 | |
| SCHEMBL5414653 | 0.77 | POLB (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL332743 | 0.77 | MEN1 (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2CNR1 | |
| SCHEMBL7002038 | 0.76 | LMNA (0.40) | P2RY14PTGER4SMN1; SMN2LMNALCK | |
| SCHEMBL28762839 | 0.76 | POLB (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL332155 | 0.76 | POLB (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |