SCHEMBL7002334

SCHEMBL7002334

CC1=C(N)Nc2cc(Cl)c([N+](=O)[O-])cc2O1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
CYP3A4 P08684 2/20 0.41
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
AKR1B1 P15121 2/20 0.38
TSHR P16473 3/20 0.35
MAPK1 P28482 1/20 0.35
MAPT P10636 3/20 0.35
MEN1 O00255 1/20 0.35
POLB P06746 1/20 0.35
KMT2A Q03164 1/20 0.35
MCL1 Q07820 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
VCAM1 P19320 1/20 0.34
PDE7A Q13946 1/20 0.34
LMNA P02545 1/20 0.34
RECQL P46063 1/20 0.33
CA12 O43570 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7000226 0.81 CHEK1 (0.39) ALDH1A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL6991146 0.74 ALDH1A1 (0.46) ALDH1A1CYP3A4TSHRMAPTMEN1
SCHEMBL7001786 0.74 TDP1 (0.46) ALDH1A1CYP3A4TSHRMAPTMEN1
SCHEMBL7001748 0.74 GRIK1 (0.49)
SCHEMBL6999113 0.72 ALDH1A1 (0.46) ALDH1A1CYP3A4TSHRMAPTMEN1
SCHEMBL754755 0.70 AKR1B1 (0.44) ALDH1A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL8118539 0.70 MAPT (0.40) ALDH1A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL7000113 0.69 PARP1 (0.44) ALDH1A1CYP3A4AKR1B1TSHRMAPK1
SCHEMBL303131 0.69 MMP12 (0.44) ALDH1A1MAPTMEN1POLBKMT2A
SCHEMBL6999139 0.69 AKR1B1 (0.39) ALDH1A1CYP3A4CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed