Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13548372 | 0.80 | ALDH1A1 (0.52) | KDM4EHTTSMN1; SMN2MERTKMAPK9 | |
| SCHEMBL3527781 | 0.79 | HTT (0.46) | KDM4EHTTSMN1; SMN2MERTKMAPK9 | |
| SCHEMBL3524028 | 0.77 | BRD9 (0.48) | KDM4EHTTSMN1; SMN2MERTKMAPK9 | |
| SCHEMBL3524171 | 0.77 | ALDH1A1 (0.47) | KDM4EFGFR1HTTSMN1; SMN2MAPK9 | |
| SCHEMBL3523275 | 0.76 | KCNH2 (0.47) | RETFGFR1HTTSMN1; SMN2MAPK9 | |
| SCHEMBL3524981 | 0.76 | ALDH1A1 (0.48) | KDM4ECLK4GSK3BHTTSMN1; SMN2 | |
| SCHEMBL3522769 | 0.72 | ALDH1A1 (0.58) | KDM4EJAK2JAK3HTTSMN1; SMN2 | |
| SCHEMBL7689517 | 0.72 | SMN1; SMN2 (0.51) | KDM4ECLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL7359530 | 0.67 | PDE4A (0.48) | KDM4EHTTSMN1; SMN2MAPK1MAP2K4 | |
| SCHEMBL7364301 | 0.67 | HTT (0.47) | KDM4EHTTSMN1; SMN2MERTKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066039-A4 | SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF | COCENSYS INC (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1066039-A1 | SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF | Cocensys, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999044612-A1 | SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF | COCENSYS, INC. (US) | 1999-09-10 | — | — | WO | disclosed |