Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3524028 | 0.83 | BRD9 (0.48) | SMN1; SMN2HTTMERTKRAB9AMAPK9 | |
| SCHEMBL13548372 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2HTTMERTKRAB9AMAPK9 | |
| SCHEMBL3527781 | 0.79 | HTT (0.46) | SMN1; SMN2HTTMERTKRAB9AMAPK9 | |
| SCHEMBL3524171 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2HTTMAPK9MAPK14KDM4E | |
| SCHEMBL3523275 | 0.76 | KCNH2 (0.47) | SMN1; SMN2HTTRAB9AMAPK9MAPK14 | |
| SCHEMBL3522769 | 0.74 | ALDH1A1 (0.58) | SMN1; SMN2HTTRAB9AKDM4EMAPT | |
| SCHEMBL3524981 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2HTTMERTKMAPK9MAPK14 | |
| SCHEMBL7002658 | 0.72 | KDM4E (0.46) | SMN1; SMN2HTTMERTKMAPK9MAPK14 | |
| SCHEMBL7359530 | 0.68 | PDE4A (0.48) | SMN1; SMN2HTTRAB9AKDM4ENPC1 | |
| SCHEMBL7364301 | 0.68 | HTT (0.47) | SMN1; SMN2HTTMERTKRAB9AMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465472-B1 | SUCH AS 1-(2-DIETHYLAMINOETHYL)-6,7-METHYLENEDIOXY-4-(3,4-METHYLENE -DIOXYPHENYL)QUINAZOLIN-2(1H)-ONE; AMPA IONOTROPIC RECEPTOR ANTAGONISTS; ANTICONVULSANTS, COGNITIVE ENHANCERS, PREVENTION OF NEURODEGENERATION | EURO-CELTIQUE S.A. (LU) | 2002-10-15 | — | — | US | disclosed |