Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.44 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995636 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1ALKBH3BRAFNR3C1 | |
| SCHEMBL6996451 | 0.89 | PTGS2 (0.44) | PTGS2PTGS1BRAFNR3C1PGR | |
| SCHEMBL7001857 | 0.88 | PTGS2 (0.40) | PTGS2PTGS1BRAFPGRPIK3CD | |
| SCHEMBL7002751 | 0.88 | PTGS2 (0.47) | PTGS2PTGS1BRAFPGRPIK3CD | |
| SCHEMBL6998443 | 0.87 | PTGS2 (0.41) | PTGS2PTGS1BRAFPGR | |
| SCHEMBL6998609 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1BRAFPIK3CDPIK3CA | |
| SCHEMBL6992554 | 0.85 | PTGS2 (0.40) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6999947 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1BRAFPIK3CDPIK3CA | |
| SCHEMBL7001355 | 0.84 | PTGS2 (0.39) | PTGS2PTGS1BRAFPGR | |
| SCHEMBL6997576 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1BRAFPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |