Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002751 | 0.91 | PTGS2 (0.47) | PTGS2PTGS1PGRBRAF | |
| SCHEMBL6994546 | 0.90 | PTGS2 (0.40) | PTGS2PTGS1NR3C1PGRNR3C2 | |
| SCHEMBL7002741 | 0.89 | PTGS2 (0.44) | PTGS2PTGS1NR3C1PGRNR3C2 | |
| SCHEMBL6995345 | 0.88 | PTGS2 (0.41) | PTGS2PTGS1BRAF | |
| SCHEMBL6998000 | 0.88 | PTGS2 (0.42) | PTGS2PTGS1NR3C1PGRNR3C2 | |
| SCHEMBL7003155 | 0.87 | PTGS2 (0.43) | PTGS2PTGS1NR3C1PGRNR3C2 | |
| SCHEMBL6993381 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1PGRBRAF | |
| SCHEMBL6999980 | 0.86 | PGR (0.40) | PTGS2PTGS1PGR | |
| SCHEMBL7001857 | 0.86 | PTGS2 (0.40) | PTGS2PTGS1PGRBRAF | |
| SCHEMBL7001382 | 0.86 | BRAF (0.42) | PTGS2PTGS1NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |