Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 7/20 | 1.00 |
| ▸ | MAOB | P27338 | 7/20 | 0.76 |
| ▸ | MAOA | P21397 | 6/20 | 0.76 |
| ▸ | CES2 | O00748 | 1/20 | 0.72 |
| ▸ | STK17B | O94768 | 1/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.68 |
| ▸ | TNF | P01375 | 2/20 | 0.68 |
| ▸ | TYR | P14679 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701204 | 1.00 | MIF (1.00) | MIFMAOBMAOACES2STK17B | |
| SCHEMBL14033556 | 0.87 | MIF (0.81) | MIFMAOBMAOACES2STK17B | |
| SCHEMBL3700238 | 0.86 | MAOB (1.00) | MIFMAOBMAOASTK17BCYP19A1 | |
| SCHEMBL2981650 | 0.86 | MAOB (1.00) | MIFMAOBMAOASTK17BCYP19A1 | |
| SCHEMBL30462578 | 0.86 | MAOB (1.00) | MIFMAOBMAOASTK17BCYP19A1 | |
| SCHEMBL3694617 | 0.86 | MAOB (1.00) | MIFMAOBMAOASTK17BCYP19A1 | |
| SCHEMBL30462577 | 0.86 | MAOB (1.00) | MIFMAOBMAOASTK17BCYP19A1 | |
| SCHEMBL30977980 | 0.86 | MAOB (1.00) | MIFMAOBMAOASTK17BCYP19A1 | |
| SCHEMBL29013407 | 0.86 | MIF (1.00) | MIFMAOBCYP19A1MEN1KMT2A | |
| SCHEMBL21169395 | 0.86 | MIF (1.00) | MIFMAOBCYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |