Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998321 | 0.87 | APP (0.67) | APPCYP1A2MEN1POLBRAB9A | |
| SCHEMBL1093926 | 0.86 | APP (0.60) | APPCYP1A2MEN1POLBRAB9A | |
| SCHEMBL119047 | 0.86 | APP (0.56) | APPCYP1A2KMT2AMAPTALDH1A1 | |
| SCHEMBL563769 | 0.85 | APP (0.66) | APPCYP1A2MEN1POLBRAB9A | |
| Ether SCHEMBL1094032 | 0.85 | APP (0.80) | APPCYP1A2MEN1POLBKMT2A | |
| SCHEMBL1104922 | 0.81 | APP (0.82) | APPCYP1A2 | |
| SCHEMBL10167845 | 0.80 | APP (0.68) | APPCYP1A2MEN1POLBRAB9A | |
| SCHEMBL738742 | 0.80 | APP (0.59) | APPCYP1A2MAPT | |
| Ethoxyresorufin SCHEMBL104497 | 0.80 | APP (1.00) | APPCYP1A2 | |
| Ethoxyresorufin SCHEMBL31079400 | 0.80 | APP (1.00) | APPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140888-B1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | VERTEX PHARMA SAN DIEGO LLC (US) | 2003-05-14 | — | — | EP | claimed |
| US-6420130-B1 | CHEMICAL COMPOUND FOR USE IN THE DETECTION OF PREFERENTIAL ENZYMATIC POLYPEPTIDE | AURORA BIOSCIENCES CORPORATION | 2002-07-16 | — | — | US | claimed |