Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7992636 | 0.99 | F2 (0.37) | F2PRSS1PRSS2PRSS3OPRM1 | |
| SCHEMBL7000162 | 0.83 | KMT2A (0.43) | F2PRSS1PRSS2PRSS3P2RX7 | |
| Hydrochloric Acid SCHEMBL7989044 | 0.83 | KMT2A (0.42) | F2PRSS1PRSS2PRSS3P2RX7 | |
| SCHEMBL6999388 | 0.82 | F2 (0.49) | F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL7978078 | 0.81 | F2 (0.49) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7299596 | 0.79 | F2 (0.40) | F2PRSS1PRSS2PRSS3POLB | |
| Hydrochloric Acid SCHEMBL7989047 | 0.79 | F2 (0.40) | F2PRSS1PRSS2PRSS3ADORA2A | |
| SCHEMBL6994837 | 0.78 | F2 (0.46) | F2PRSS1PRSS2PRSS3POLB | |
| Hydrochloric Acid SCHEMBL7989423 | 0.77 | F2 (0.45) | F2PRSS1PRSS2PRSS3POLB | |
| SCHEMBL6994847 | 0.76 | F2 (0.40) | F2PRSS1PRSS2PRSS3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |