SCHEMBL7002989

SCHEMBL7002989

CN(C)[N]Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
TSHR P16473 1/20 0.48
AOC3 Q16853 3/20 0.44
TAAR1 Q96RJ0 1/20 0.44
NOS2 P35228 1/20 0.43
TRPA1 O75762 1/20 0.43
CYP3A4 P08684 1/20 0.43
MIF P14174 1/20 0.43
HPGD P15428 1/20 0.43
TP53 P04637 1/20 0.42
VSIR Q9H7M9 1/20 0.42
LMNA P02545 2/20 0.41
CHKA P35790 2/20 0.41
HTT P42858 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CALM1 P0DP23 1/20 0.39
CARM1 Q86X55 1/20 0.39
PRMT6 Q96LA8 1/20 0.39
PRMT8 Q9NR22 1/20 0.39
SIGMAR1 Q99720 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11046745 0.76 TP53 (0.44) ALDH1A1TSHRAOC3TAAR1NOS2
SCHEMBL1793162 0.73 G6PC1 (0.50) ALDH1A1TSHRAOC3NOS2TRPA1
SCHEMBL1653 0.72 ALDH1A1 (0.55) ALDH1A1TSHRTAAR1NOS2TRPA1
SCHEMBL2270 0.70
SCHEMBL1506483 0.70
SCHEMBL17761948 0.70 ALDH1A1 (0.43) ALDH1A1TSHRAOC3TAAR1NOS2
SCHEMBL7265536 0.70 ALDH1A1 (0.43) ALDH1A1TSHRAOC3TAAR1NOS2
SCHEMBL7265542 0.70 ALDH1A1 (0.43) ALDH1A1TSHRAOC3TAAR1NOS2
SCHEMBL10371085 0.70 GRIN2B (0.53) ALDH1A1TSHRAOC3TAAR1NOS2
SCHEMBL17178869 0.69 ALDH1A1 (0.52) ALDH1A1TSHRTAAR1NOS2TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1155001-A4 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES LION BIOSCIENCE AG (DE) 2003-05-28 EP claimed
EP-1155001-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 2001-11-21 EP claimed
WO-2000050406-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES LION BIOSCIENCE AG (DE) 2000-08-31 WO claimed
US-4477664-A CARCINOSTATIC ACTIVITY, LOW TOXICITY, INTERMEDIATES TOYAMA CHEMICAL CO., LTD. (JP) 1984-10-16 US disclosed
US-4477666-A ANTICARCINO GENIC AGENTS TOYAMA CHEMICAL CO., LTD. (JP) 1984-10-16 US disclosed
US-4460774-A ANTICARCINOGENIC AGENTS TOYAMA CHEMICAL COMPANY, LIMITED (JP) 1984-07-17 US disclosed
US-4459407-A ANTICARCINOGENIC TOYAMA CHEMICAL CO., LTD. (JP) 1984-07-10 US disclosed
US-4448963-A ANTICARCINOGENS TOYAMA CHEMICAL CO., LTD. (JP) 1984-05-15 US disclosed
US-4436921-A CARCINOSTATIC ACTIVITY TOYAMA CHEMICAL CO., LTD. (JP) 1984-03-13 US disclosed