Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17286012 | 0.92 | ACHE (0.54) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL7523207 | 0.92 | SLC6A3 (0.57) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL17284517 | 0.91 | SLC6A3 (0.52) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL22878369 | 0.91 | SLC6A3 (0.52) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL7383124 | 0.88 | SLC6A3 (0.53) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL7383573 | 0.88 | HRH3 (0.58) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL7383126 | 0.88 | SLC6A3 (0.53) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL7385498 | 0.88 | HRH3 (0.58) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL13755814 | 0.88 | SLC6A3 (0.58) | SLC6A3SIGMAR1ACHEGBA1CCR3 | |
| SCHEMBL7383578 | 0.88 | HRH3 (0.58) | SLC6A3SIGMAR1ACHEGBA1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360187-A1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-11-12 | — | — | EP | claimed |
| WO-2002060902-A1 | 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-08-08 | — | — | WO | claimed |
| EP-1360187-A1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002060902-A1 | 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-08-08 | — | — | WO | disclosed |