Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003153 | 0.93 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL7001412 | 0.81 | GAA (0.49) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL7001420 | 0.77 | GAA (0.47) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL2769301 | 0.72 | LMNA (0.47) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL7002038 | 0.71 | LMNA (0.40) | SMN1; SMN2LMNACNR1 | |
| SCHEMBL31133143 | 0.71 | NPSR1 (0.43) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL331349 | 0.70 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL6807697 | 0.70 | CCNA2 (0.37) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL20670974 | 0.69 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL6443054 | 0.68 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1KDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |