SCHEMBL7003284

SCHEMBL7003284

Cc1cc(Br)cc2c1cc1c(=O)[nH]ccn12

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 3/20 0.53
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7006748 0.73 BRD4 (0.45) BRD4TP53
SCHEMBL21190756 0.69 BRD4 (1.00) BRD4
SCHEMBL27185218 0.67 PARP1 (0.46) BRD4
SCHEMBL31510106 0.67 PARP1 (0.46) BRD4
SCHEMBL7001371 0.67 BRD4 (0.45) BRD4
SCHEMBL25080083 0.65 BRD4 (0.39) BRD4
SCHEMBL4751214 0.64 PARP1 (0.41) BRD4TP53
SCHEMBL16576928 0.63 BRD4 (0.47) BRD4TP53
SCHEMBL7005666 0.61 DAO (0.41) BRD4
SCHEMBL2898166 0.61 BRD4 (0.42) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1200439-B1 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES NOVUSPHARMA SPA (IT) 2003-06-25 EP disclosed