Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001371 | 0.80 | BRD4 (0.45) | BRD4CHEK1CYP2A6PIM1RPS6KA3 | |
| SCHEMBL7002739 | 0.80 | GRIA1 (0.39) | BRD4AHRJAK2JAK3 | |
| SCHEMBL7005550 | 0.80 | CHEK1 (0.45) | BRD4AHRCHEK1 | |
| SCHEMBL7005666 | 0.78 | DAO (0.41) | BRD4CYP2A6TYMS | |
| SCHEMBL4751214 | 0.77 | PARP1 (0.41) | BRD4TP53CHEK1PIM1JAK2 | |
| SCHEMBL7004919 | 0.76 | MEN1 (0.42) | BRD4CYP2A6 | |
| SCHEMBL7010349 | 0.75 | BRD4 (0.43) | BRD4 | |
| SCHEMBL7006207 | 0.75 | GRIA1 (0.41) | — | |
| SCHEMBL7003284 | 0.73 | BRD4 (0.53) | BRD4TP53 | |
| SCHEMBL7007056 | 0.73 | CES1 (0.38) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |