Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.46 |
| ▸ | SOAT2 | O75908 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998288 | 0.85 | XDH (0.44) | SOAT1SOAT2ENPP2DGAT2TSHR | |
| SCHEMBL7002343 | 0.85 | EPHX2 (0.46) | HDAC1HDAC2EPHX2SOAT1SOAT2 | |
| SCHEMBL6995177 | 0.85 | EPHX2 (0.46) | HDAC1HDAC2EPHX2SOAT1SOAT2 | |
| SCHEMBL7001501 | 0.85 | EPHX2 (0.46) | HDAC1HDAC2EPHX2SOAT1SOAT2 | |
| SCHEMBL7002759 | 0.83 | TSHR (0.44) | HDAC1HDAC2EPHX2SOAT1SOAT2 | |
| SCHEMBL7987935 | 0.81 | XDH (0.47) | HDAC1HDAC2EPHX2SOAT1SOAT2 | |
| SCHEMBL7002481 | 0.80 | TSHR (0.48) | HDAC1HDAC2EPHX2TSHRPOLB | |
| SCHEMBL7827505 | 0.79 | XDH (0.45) | SOAT1SOAT2KMT2ATSHRPOLB | |
| SCHEMBL7991550 | 0.78 | GAA (0.45) | HDAC1HDAC2EPHX2TSHRPOLB | |
| SCHEMBL7003613 | 0.75 | ADORA1 (0.46) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069126-B1 | TRIAZOLOPURINE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVES, ADENOSINE A3 RECEPTOR COMPATIBILIZING AGENT, AND ASTHMATIC REMEDY | OTSUKA PHARMA CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-6288070-B1 | Triazolopurine derivatives, medicinal composition containing the derivatives, adenosine A3 receptor compatibilizing agent, and asthmatic remedy | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-09-11 | — | — | US | disclosed |
| EP-1069126-A1 | TRIAZOLOPURINE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVES, ADENOSINE A3 RECEPTOR COMPATIBILIZING AGENT, AND ASTHMATIC REMEDY | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-01-17 | — | — | EP | disclosed |