Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655667 | 0.81 | GABRA1 (0.41) | LRRK2 | |
| SCHEMBL7005941 | 0.77 | GABRA1 (0.49) | LRRK2 | |
| SCHEMBL7004128 | 0.76 | GABRA1 (0.39) | LRRK2 | |
| SCHEMBL7001260 | 0.76 | GABRG2 (0.46) | — | |
| SCHEMBL7006675 | 0.71 | LRRK2 (0.35) | LRRK2 | |
| SCHEMBL6998762 | 0.63 | GABRA1 (0.47) | — | |
| SCHEMBL7005499 | 0.63 | GABRA1 (0.43) | — | |
| SCHEMBL7003973 | 0.62 | GABRA1 (0.52) | — | |
| SCHEMBL6999458 | 0.62 | GABRA1 (0.66) | — | |
| SCHEMBL7006134 | 0.62 | GABRA1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |