Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31226190 | 0.90 | MAPT (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL19578582 | 0.84 | NOTUM (0.39) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL19578262 | 0.82 | GABRA1 (0.31) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7001174 | 0.81 | ALDH1A1 (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2657155 | 0.81 | ALDH1A1 (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL19578583 | 0.80 | GABRA1 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL23529930 | 0.79 | STAT3 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL31226333 | 0.78 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL31226222 | 0.78 | ALDH1A1 (0.34) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL31226119 | 0.77 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117088885-A | Triazolopyridazine compound and application thereof | 上海赛默罗生物科技有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114591352-B | Triazolopyridazine compound and application thereof | 上海赛默罗生物科技有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114591352-A | Triazolopyridazine compound and application thereof | 上海赛默罗生物科技有限公司 | 2022-06-07 | — | — | CN | disclosed |
| WO-2017190707-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 如东赛默罗生物科技有限公司 | 2017-11-09 | — | — | WO | disclosed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |
| US-6444666-B1 | SUCH AS ALZHEIMER'S DISEASE; SUBSTITUTED 1,2,4-TRIAZOLO(4,3-B) PYRIDAZINE DERIVATIVES ARE LIGANDS FOR GABA RECEPTORS; CONVULSANT ACTIVITY IS REDUCED OR ELIMINATED | MERCK SHARP & DOHME LTD. (GB) | 2002-09-03 | — | — | US | disclosed |
| US-6297235-B1 | ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2001-10-02 | — | — | US | disclosed |