Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.50 |
| ▸ | MECP2 | P51608 | 1/20 | 0.50 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.50 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.50 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.50 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | KDM4B | O94953 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18249866 | 0.83 | CYP19A1 (0.56) | CYP19A1ADAMTS5SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL2224538 | 0.77 | ALDH1A1 (0.55) | CYP19A1ADAMTS5SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL31606784 | 0.74 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL14156978 | 0.74 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL1741719 | 0.74 | CYP19A1 (0.79) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL128834 | 0.74 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL29516285 | 0.74 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL7003561 | 0.73 | KDM4E (0.49) | CYP19A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL10272523 | 0.73 | CYP19A1 (0.61) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL5132347 | 0.73 | CYP19A1 (0.61) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531466-B2 | E.g., a 1-aza-10-(1-hydroxyethyl-11-oxo-4-(het-methylene)-tricyclo(7.2 .0.0(3,8))undec-2-ene-2-carboxylate; good activity against grampositive bacteria such as methicillin-resistant Staphylococcus aureus and epidermidis | GLAXOSMITHKLINE SPA (IT) | 2003-03-11 | — | — | US | disclosed |
| EP-0937078-B1 | TRICYCLIC CARBAPENEM COMPOUNDS | GLAXOSMITHKLINE SPA (IT) | 2003-02-12 | — | — | EP | disclosed |
| EP-0937078-A1 | TRICYCLIC CARBAPENEM COMPOUNDS | GLAXO WELLCOME S.p.A. (IT) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998021210-A1 | TRICYCLIC CARBAPENEM COMPOUNDS | GLAXO WELLCOME S.P.A. (IT) | 1998-05-22 | — | — | WO | disclosed |