Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29752706 | 1.00 | ACHE (0.67) | ACHE | |
| SCHEMBL30666981 | 0.88 | ACHE (0.53) | ACHE | |
| SCHEMBL1694272 | 0.83 | ACHE (0.54) | ACHE | |
| SCHEMBL9741674 | 0.82 | ACHE (0.67) | ACHE | |
| SCHEMBL8938844 | 0.80 | ACHE (1.00) | ACHE | |
| SCHEMBL29369832 | 0.79 | ACHE (0.67) | ACHE | |
| SCHEMBL8522007 | 0.79 | ACHE (0.67) | ACHE | |
| SCHEMBL11803054 | 0.78 | ACHE (0.52) | ACHE | |
| SCHEMBL10427199 | 0.77 | ACHE (0.65) | ACHE | |
| SCHEMBL4462617 | 0.76 | METAP1 (0.58) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150293-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | VERNALIS (R&D) LTD (GB) | 2024-05-09 | — | — | US | disclosed |
| EP-4277892-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | Les Laboratoires Servier (FR) | 2023-11-22 | — | — | EP | disclosed |
| CN-116940552-A | Spirocyclic hexane derivatives, pharmaceutical compositions containing them and their use as anti-apoptotic inhibitors | 法国施维雅药厂 | 2023-10-24 | — | — | CN | disclosed |
| CN-114671829-B | Heterodiad taking indenone and dibenzoazepine as parent nucleus and hydrochloride thereof, preparation method and application thereof | 合肥工业大学 | 2023-07-25 | — | — | CN | disclosed |
| WO-2022152705-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-07-21 | — | — | WO | disclosed |
| CN-114671829-A | Heterodiad with indanone and dibenzoazepine as parent nucleus, hydrochloride thereof, preparation method and application thereof | 合肥工业大学 | 2022-06-28 | — | — | CN | disclosed |
| US-20160016860-A1 | METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS | DUBLIN CITY UNIVERSITY (IE) | 2016-01-21 | — | — | US | disclosed |
| US-20160016860-A1 | METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS | DUBLIN CITY UNIVERSITY (IE) | 2016-01-21 | — | — | US | disclosed |
| EP-2970347-A1 | METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS | Dublin City University (IE) | 2016-01-20 | — | — | EP | disclosed |
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-06 | — | — | US | disclosed |
| EP-1841739-A1 | PROCESS FOR PRODUCING 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON2-YL)METHYL] PIPERIDINE OR ITS SALT THEREOF VIA NOVEL INTERMEDIATE | Jubilant Organosys Limited (IN) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006070396-A1 | PROCESS FOR PRODUCING 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON2-YL)METHYL] PIPERIDINE OR ITS SALT THEREOF VIA NOVEL INTERMEDIATE | JUBILANT ORGANOSYS LIMITED (IN) | 2006-07-06 | — | — | WO | disclosed |
| WO-2005076749-A2 | A NOVEL PROCESS FOR THE PREPARATION OF 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE | JUBILANT ORGANOSYS LIMITED (IN) | 2005-08-25 | — | — | WO | disclosed |
| US-4826975-A | HYPOTENSIVE, ANTICOAGULANT, ANTILIPEMIC | MAGGIONI-WINTHROP S.P.A. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0199393-B1 | INDENE AND NAPHTHALENE DERIVATIVES | AKZO N.V. (NL) | 1988-12-07 | — | — | EP | disclosed |
| US-4705782-A | Indene and naphthalene derivatives | AKZO N.V. (NL) | 1987-11-10 | — | — | US | disclosed |
| WO-1987002035-A1 | FUSED CYCLOALIPHATIC AMINOALCOHOLS | MAGGIONI-WINTHROP S.P.A. (IT) | 1987-04-09 | — | — | WO | disclosed |
| EP-0199393-A1 | Indene and naphthalene derivatives | AKZO N.V. (NL) | 1986-10-29 | — | — | EP | disclosed |
| US-3954983-A | CENTRAL NERVOUS SYSTEM ANTIDEPRESSANTS | RICHARDSON-MERRELL INC. (US) | 1976-05-04 | — | — | US | disclosed |
| US-3932430-A | Substituted indeno, naphtho and cyclohepta pyrazoles | SANDOZ, INC. (US) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016860-A1 | METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS | DCXR, TECR, PWWP2B | ACHE 501/4885 |
| US-20240150293-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | BCL2, BAX, BCL2A1 | ACHE 4262/4885 |
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | PRNP, PSEN1, PSEN2 | ACHE 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.