Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31115697 | 0.86 | APP (1.00) | APPCYP1A2NPC1RAB9ALMNA | |
| SCHEMBL563392 | 0.86 | APP (1.00) | APPCYP1A2NPC1RAB9ALMNA | |
| SCHEMBL1104921 | 0.86 | APP (1.00) | APPCYP1A2NPC1RAB9AKMT2A | |
| SCHEMBL1094100 | 0.85 | APP (0.59) | APPCYP1A2RAB9AKMT2APOLB | |
| SCHEMBL10167882 | 0.83 | APP (1.00) | APPCYP1A2NPC1RAB9A | |
| SCHEMBL6998321 | 0.83 | APP (0.67) | APPCYP1A2NPC1RAB9AKMT2A | |
| SCHEMBL563769 | 0.81 | APP (0.66) | APPCYP1A2NPC1RAB9AKMT2A | |
| SCHEMBL10167883 | 0.81 | APP (0.93) | APPCYP1A2 | |
| SCHEMBL10167845 | 0.78 | APP (0.68) | APPCYP1A2RAB9AKMT2APOLB | |
| SCHEMBL7002876 | 0.78 | APP (0.66) | APPCYP1A2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140888-B1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | VERTEX PHARMA SAN DIEGO LLC (US) | 2003-05-14 | — | — | EP | claimed |
| US-6143492-A | COMPOUND USEFUL AS AN OPTICAL PROBE; DRUG SCREENING | AURORA BIOSCIENCES CORPORATION (US) | 2000-11-07 | — | — | US | claimed |