Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093926 | 0.86 | APP (0.60) | APPCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7004388 | 0.85 | APP (0.76) | APPCYP1A2POLBRAB9AKMT2A | |
| SCHEMBL10167845 | 0.82 | APP (0.68) | APPCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL563769 | 0.82 | APP (0.66) | APPCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL19627054 | 0.80 | APP (0.54) | APPCYP1A2 | |
| SCHEMBL29809000 | 0.80 | APP (0.79) | APPCYP1A2MEN1RAB9AKMT2A | |
| SCHEMBL563335 | 0.80 | APP (0.79) | APPCYP1A2MEN1RAB9AKMT2A | |
| SCHEMBL10208641 | 0.80 | APP (0.64) | APPCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL563608 | 0.80 | APP (0.63) | APPCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL1072207 | 0.79 | APP (0.74) | APPCYP1A2MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106544399-B | Application of high-specificity fluorescent probe for detecting cytochrome P4501A1 | 苏州尚稷电子科技有限公司 | 2020-04-03 | — | — | CN | disclosed |
| US-8153828-B2 | Optical molecular sensors for cytochrome P450 activity | Life Technologies Corporation (US) | 2012-04-10 | — | — | US | disclosed |
| US-20100105095-A1 | Optical Molecular Sensors for Cytochrome P450 Activity | Life Technologies Corporation (US) | 2010-04-29 | — | — | US | disclosed |
| US-20090239761-A1 | Protein arrays and uses thereof | SENSE PROTEOMIC LIMITED (GB) | 2009-09-24 | — | — | US | disclosed |
| US-20080125586-A1 | Optical molecular sensors for cytochrome P450 activity | INVITROGEN CORPORATION (US) | 2008-05-29 | — | — | US | disclosed |
| US-20070072256-A1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | INVITROGEN CORPORATION | 2007-03-29 | — | — | US | disclosed |
| US-7132252-B2 | Comprises fluorophores selected from 7-hydroxycoumarin derivtives, resorufin, and a fluorescein; drug screening | INVITROGEN CORPORATION (US) | 2006-11-07 | — | — | US | disclosed |
| US-20060199220-A1 | Protein arrays and uses thereof | BLACKBURN JONATHAN M | 2006-09-07 | — | — | US | disclosed |
| US-6638713-B2 | Measurement of cytochrome enzymatic activity; obtain sample containing cytochrome, incubate with labeled substrate, monitor adjustments in optical signal, compare to control, quantify | AURORA BIOSCIENCES CORPORATION | 2003-10-28 | — | — | US | disclosed |
| US-20030186349-A1 | Optical molecular sensors for cytochrome P450 activity | Life Technologies Corporation | 2003-10-02 | — | — | US | disclosed |
| EP-1140888-B1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | VERTEX PHARMA SAN DIEGO LLC (US) | 2003-05-14 | — | — | EP | disclosed |
| US-20030027238-A1 | Optical molecular sensors for cytochrome P450 activity | Life Technologies Corporation | 2003-02-06 | — | — | US | disclosed |
| US-6514687-B1 | Screening a candidate compound for activity as a Cytochrome P450 enzyme substrate by contacting the compound, enzyme, and a reagent chromogen comprising the ether of a phenolic dye such as a coumarin, resofurin or fluorescein dye | VERTEX PHARMACEUTICALS (SAN DIEGO), LLC | 2003-02-04 | — | — | US | disclosed |
| US-6420130-B1 | CHEMICAL COMPOUND FOR USE IN THE DETECTION OF PREFERENTIAL ENZYMATIC POLYPEPTIDE | AURORA BIOSCIENCES CORPORATION | 2002-07-16 | — | — | US | disclosed |
| EP-1140888-A1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | Aurora Biosciences Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6143492-A | COMPOUND USEFUL AS AN OPTICAL PROBE; DRUG SCREENING | AURORA BIOSCIENCES CORPORATION (US) | 2000-11-07 | — | — | US | disclosed |
| WO-2000035900-A1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | AURORA BIOSCIENCES CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105095-A1 | Optical Molecular Sensors for Cytochrome P450 Activity | CYP2J2, CYP1A2, CYP2B6 | APP 3233/4885CYP1A2 2/4885KDM4E 1411/4885 |
| US-20080125586-A1 | Optical molecular sensors for cytochrome P450 activity | CYP2J2, CYP1A2, CYP2B6 | APP 3233/4885CYP1A2 2/4885KDM4E 1411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.