Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003930 | 0.76 | MAPT (0.56) | ALDH1A1MAPTGAAPOLBHTT | |
| SCHEMBL14310603 | 0.73 | KDM4E (0.74) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL12046967 | 0.72 | KDM4E (0.76) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL5717769 | 0.72 | CHRM1 (0.74) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL6998783 | 0.72 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL20561440 | 0.71 | MAPT (0.75) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL13126366 | 0.70 | MAPK8 (0.58) | ALDH1A1TDP1POLBHTT | |
| Procodazole SCHEMBL5413283 | 0.70 | CHRM1 (0.91) | CYP1A2KDM4EALDH1A1MAPTCHRM1 | |
| SCHEMBL12414218 | 0.69 | MMP2 (0.60) | KDM4ESMN1; SMN2MAPTGAA | |
| SCHEMBL4573158 | 0.69 | CHRM1 (0.74) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |