Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | DHPS | P49366 | 2/20 | 0.44 |
| ▸ | GRK2 | P25098 | 4/20 | 0.42 |
| ▸ | GRK1 | Q15835 | 2/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002674 | 0.85 | GRK2 (0.52) | KDM4EL3MBTL1POLBSMN1; SMN2LMNA | |
| SCHEMBL7003741 | 0.84 | KDM4E (0.49) | KDM4EL3MBTL1HSD17B10CNOT7ROCK2 | |
| SCHEMBL7003110 | 0.79 | TP53 (0.53) | PKMLMNA | |
| SCHEMBL7004560 | 0.78 | SMN1; SMN2 (0.52) | KDM4EL3MBTL1SMN1; SMN2PKMLMNA | |
| SCHEMBL7002562 | 0.77 | KDM4E (0.53) | KDM4ESMN1; SMN2PKMHSD17B10LMNA | |
| SCHEMBL7002957 | 0.75 | KDM4E (0.47) | KDM4EPOLBHTTCNOT7GRK2 | |
| SCHEMBL7002186 | 0.74 | TSHR (0.45) | KDM4EL3MBTL1POLBLMNAHTT | |
| SCHEMBL7004474 | 0.73 | ALDH1A1 (0.51) | KDM4EPOLBSMN1; SMN2HSD17B10LMNA | |
| SCHEMBL7002396 | 0.73 | SMN1; SMN2 (0.62) | KDM4EL3MBTL1POLBSMN1; SMN2LMNA | |
| SCHEMBL12761304 | 0.72 | RAB9A (0.40) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030186997-A1 | 2,5-Dihydro-pyrazolo[3,4-d]pyrimidin-4-ones with an anticonsulsive action and methods for producing the same | ELBION AG (DE) | 2003-10-02 | — | — | US | claimed |
| US-20030186997-A1 | 2,5-Dihydro-pyrazolo[3,4-d]pyrimidin-4-ones with an anticonsulsive action and methods for producing the same | ELBION AG (DE) | 2003-10-02 | — | — | US | disclosed |
| EP-1311510-A1 | 2,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002018387-A1 | 2,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ELBION AG (DE) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186997-A1 | 2,5-Dihydro-pyrazolo[3,4-d]pyrimidin-4-ones with an anticonsulsive action and methods for producing the same | DDO, GRIN3A, GRIK4 | KDM4E 1874/4885L3MBTL1 4609/4885POLB 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.