Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743962 | 0.87 | DPP4 (0.49) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| SCHEMBL2536966 | 0.87 | DPP4 (0.49) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| SCHEMBL2536963 | 0.87 | DPP4 (0.49) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL3743959 | 0.85 | DPP4 (0.48) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL3743965 | 0.85 | DPP4 (0.48) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| SCHEMBL7011991 | 0.78 | OPRD1 (0.51) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| SCHEMBL4902378 | 0.78 | OPRD1 (0.51) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL4902375 | 0.77 | OPRD1 (0.50) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL7008761 | 0.77 | OPRD1 (0.50) | TP53SMN1; SMN2RXFP1DPP4DPP8 | |
| SCHEMBL24709579 | 0.73 | CYP2A6 (0.53) | TP53SMN1; SMN2RXFP1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285671-B1 | PYRIDINE DERIVATIVES | ASAHI CHEMICAL IND (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-5126448-A | Anxiolytic agents, learning enhancement | ASAHI KASEI KOGYO K.K. (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0285671-A1 | PYRIDINE DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 1988-10-12 | — | — | EP | disclosed |