Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27466060 | 0.83 | EGFR (0.30) | — | |
| SCHEMBL6999320 | 0.82 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL27466572 | 0.72 | PTGS2 (0.38) | PTGS2PTGS1SLC6A4ALDH1A1POLB | |
| SCHEMBL27548524 | 0.72 | SIGMAR1 (0.33) | PTGS2PTGS1POLBEDNRA | |
| SCHEMBL6993661 | 0.72 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL6994616 | 0.71 | SIGMAR1 (0.46) | PTGS2PTGS1SLC6A4ALDH1A1POLB | |
| SCHEMBL6994235 | 0.70 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL6994402 | 0.70 | PTGS2 (0.58) | PTGS2PTGS1ALDH1A1GSK3B | |
| SCHEMBL6998108 | 0.69 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL27467460 | 0.69 | TP53 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |