Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30909106 | 1.00 | HTR1F (0.48) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7009335 | 0.97 | HTR1F (0.47) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL30909164 | 0.97 | HTR1F (0.47) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7014159 | 0.89 | HTR1F (0.45) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7095378 | 0.85 | HTR1F (0.54) | HTR1FSLC6A4KDM4ELMNAHTR1A | |
| SCHEMBL7013302 | 0.84 | HTR1F (0.46) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL30909216 | 0.84 | HTR1F (0.46) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7010491 | 0.83 | HTR1F (0.49) | HTR1FSLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7012228 | 0.81 | HTR1F (0.55) | HTR1FKDM4ELMNAHTR1AALOX15 | |
| SCHEMBL7007191 | 0.77 | HTR1F (0.48) | HTR1FSLC6A4KDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916670-B1 | Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0916670-A2 | Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |