Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008527 | 0.85 | BAZ2B (0.45) | KMT2AKDM4EMEN1RAB9ACYP2C9 | |
| SCHEMBL7555153 | 0.79 | BRD4 (0.36) | KMT2ABRD4KDM4EGRIA4GRIA2 | |
| SCHEMBL1081579 | 0.70 | GRIA4 (0.47) | KMT2ABRD4KDM4EGRIA4GRIA2 | |
| SCHEMBL1381646 | 0.69 | HK2 (0.40) | BRD4GRIA4GRIA2CREBBPFABP3 | |
| SCHEMBL1254367 | 0.67 | BRD4 (0.47) | KMT2ABRD4KDM4EGRIA4GRIA2 | |
| SCHEMBL8287396 | 0.66 | GRIA4 (0.59) | GRIA4GRIA2 | |
| SCHEMBL5231452 | 0.66 | DPP4 (0.46) | GRIA4GRIA2 | |
| SCHEMBL31154485 | 0.64 | CYP2C9 (0.37) | KMT2AKDM4EMEN1PKMCYP2C9 | |
| SCHEMBL2637715 | 0.64 | GRIA2 (0.45) | KDM4EGRIA4GRIA2RAB9A | |
| SCHEMBL8289845 | 0.64 | GRIA4 (0.57) | KDM4EGRIA4GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |