Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005559 | 0.85 | KMT2A (0.42) | CYP2C9RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL7008752 | 0.83 | BAZ2B (0.48) | BAZ2BBAZ2ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL3825512 | 0.78 | TSHR (0.45) | CYP1A2CYP2C19CYP2C9TSHRJMJD6 | |
| SCHEMBL7002598 | 0.77 | CRHBP (0.53) | CYP1A2CYP2C19CYP2C9TSHRALDH1A1 | |
| SCHEMBL1748814 | 0.77 | ALDH1A1 (0.51) | CYP1A2CYP2C19CYP2C9TSHRALDH1A1 | |
| SCHEMBL6106131 | 0.71 | TSHR (0.50) | BAZ2BBAZ2ACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL7005984 | 0.71 | BAZ2B (0.40) | BAZ2BBAZ2ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL12992021 | 0.71 | CYP1A2 (0.52) | CYP1A2CYP2C19CSF1RALDH1A1RAB9A | |
| SCHEMBL7004554 | 0.70 | BAZ2B (0.39) | BAZ2BBAZ2ACYP1A2CYP2C19TSHR | |
| SCHEMBL7006924 | 0.70 | CRHBP (0.44) | TSHRALDH1A1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A9 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |