Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007509 | 0.86 | HPGD (0.44) | ALDH1A1HPGDKDM4EL3MBTL1POLB | |
| SCHEMBL7012519 | 0.86 | ERCC1 (0.35) | ALDH1A1MAPTHPGDKDM4EMAOB | |
| SCHEMBL7013231 | 0.85 | POLB (0.46) | LMNAALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL7011565 | 0.72 | CYP1A2 (0.34) | ALDH1A1DAO | |
| SCHEMBL7007761 | 0.71 | MCL1 (0.33) | TSHRALDH1A1KDM4EPOLBDAO | |
| SCHEMBL12883186 | 0.68 | TSHR (0.77) | TSHRLMNAALDH1A1MAPTHPGD | |
| SCHEMBL7008607 | 0.67 | KDM4E (0.43) | TSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7007080 | 0.67 | MAPT (0.39) | LMNAALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL7013173 | 0.65 | TYMS (0.32) | ALDH1A1MAPTDAO | |
| SCHEMBL12240557 | 0.63 | CYP3A4 (0.59) | TSHRLMNAALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | disclosed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6015820-A | VIRICIDES; AIDS TREATMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2000-01-18 | — | — | US | disclosed |
| EP-0843663-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997005113-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1997-02-13 | — | — | WO | disclosed |