SCHEMBL7013231

SCHEMBL7013231

Cc1cc(C)cc(Sc2c(C)c[nH]c(=O)c2NC(=O)Cc2ccccc2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C19 P33261 1/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.44
HPGD P15428 2/20 0.43
L3MBTL1 Q9Y468 3/20 0.41
ALDH1A1 P00352 2/20 0.41
ROCK2 O75116 3/20 0.40
CDC42 P60953 1/20 0.40
ROCK1 Q13464 1/20 0.40
PKN2 Q16513 1/20 0.40
LMNA P02545 2/20 0.40
ATM Q13315 1/20 0.40
RAB9A P51151 3/20 0.40
GALR3 O60755 1/20 0.40
HTT P42858 1/20 0.40
GAA P10253 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7005587 0.85 TSHR (0.44) POLBHPGDL3MBTL1ALDH1A1LMNA
SCHEMBL7007509 0.79 HPGD (0.44) POLBKMT2ASMN1; SMN2HPGDL3MBTL1
Hydrochloric Acid SCHEMBL30124838 0.72 POLB (0.66) POLBCYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL27871203 0.69 KMT2A (0.73) KMT2AMEN1SMN1; SMN2HPGDL3MBTL1
SCHEMBL13541545 0.68 HPGD (0.70) POLBCYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL7011565 0.66 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C19ALDH1A1GAA
SCHEMBL28268613 0.64 RAB9A (0.75) POLBCYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL7008607 0.63 KDM4E (0.43) KMT2AMEN1SMN1; SMN2ALDH1A1ATM
SCHEMBL10062811 0.63 ITK (0.68)
SCHEMBL21388008 0.62 HPGD (0.52) POLBCYP1A2CYP3A4CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0843663-B9 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES CENTRE NAT RECH SCIENT (FR) 2003-10-29 EP disclosed
EP-0843663-B1 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES CENTRE NAT RECH SCIENT (FR) 2003-04-09 EP disclosed
US-6015820-A VIRICIDES; AIDS TREATMENT CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2000-01-18 US disclosed
WO-1997005113-A1 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1997-02-13 WO disclosed