Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 7/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 7/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 7/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011304 | 0.87 | SMN1; SMN2 (0.44) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7009673 | 0.85 | KDM4E (0.40) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7014254 | 0.83 | MEN1 (0.43) | KDM4ETSHRMEN1KMT2ANTSR1 | |
| SCHEMBL7007536 | 0.79 | KDM4E (0.35) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7007761 | 0.76 | MCL1 (0.33) | KDM4ETSHRTYMSALDH1A1 | |
| SCHEMBL7009670 | 0.73 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7145066 | 0.72 | GRIN2D (0.52) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8081511 | 0.72 | GFER (0.37) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8081107 | 0.72 | GAA (0.54) | KDM4ETSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8072217 | 0.71 | ALDH1A1 (0.49) | KDM4EMEN1KMT2ANTSR1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | disclosed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6015820-A | VIRICIDES; AIDS TREATMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2000-01-18 | — | — | US | disclosed |
| EP-0843663-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997005113-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1997-02-13 | — | — | WO | disclosed |