Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997542 | 0.85 | SLC6A4 (0.41) | MAPTNR1H2NR1H3DRD2DRD3 | |
| SCHEMBL16394026 | 0.85 | SLC6A4 (0.41) | MAPTNR1H2NR1H3DRD2DRD3 | |
| SCHEMBL19034819 | 0.84 | MAPT (0.48) | MAPTNR1H2NR1H3DRD2DRD3 | |
| SCHEMBL5744290 | 0.81 | SLC6A4 (0.46) | MAPTNR1H2NR1H3DRD2DRD3 | |
| SCHEMBL16023501 | 0.77 | PDK1 (0.36) | MAPTNR1H2NR1H3DRD2DRD3 | |
| SCHEMBL17427527 | 0.77 | PDK1 (0.36) | MAPTNR1H2NR1H3DRD2DRD3 | |
| SCHEMBL5745904 | 0.76 | NR1H2 (0.43) | MAPTNR1H2NR1H3SIGMAR1 | |
| SCHEMBL16025064 | 0.73 | MAPT (0.54) | MAPTNR1H2NR1H3HRH2 | |
| SCHEMBL7241221 | 0.72 | SLC6A4 (0.40) | NR1H2NR1H3SLC6A4SIGMAR1 | |
| SCHEMBL4193483 | 0.71 | RECQL (0.48) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368354-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070523-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |