Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385280 | 1.00 | FFAR1 (0.62) | FFAR1ALOX5KCNH2SLC9A1FFAR4 | |
| SCHEMBL2778222 | 0.85 | FFAR1 (0.62) | FFAR1KCNH2SLC9A1HDAC4NPC1 | |
| SCHEMBL2778223 | 0.85 | FFAR1 (0.62) | FFAR1KCNH2SLC9A1HDAC4NPC1 | |
| SCHEMBL24737951 | 0.84 | SLC9A1 (0.67) | FFAR1SLC9A1 | |
| SCHEMBL21501023 | 0.84 | SLC9A1 (0.67) | FFAR1SLC9A1 | |
| SCHEMBL7003208 | 0.84 | SLC9A1 (0.67) | FFAR1SLC9A1 | |
| SCHEMBL10288769 | 0.84 | SLC9A1 (0.67) | FFAR1SLC9A1 | |
| SCHEMBL7003204 | 0.84 | SLC9A1 (0.67) | FFAR1SLC9A1 | |
| SCHEMBL1207144 | 0.84 | SLC9A1 (0.67) | FFAR1SLC9A1 | |
| SCHEMBL2136314 | 0.82 | SLC9A1 (0.47) | FFAR1ALOX5SLC9A1HDAC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |