Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 11/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004742 | 0.80 | MAPT (0.37) | LMNARAB9A | |
| SCHEMBL7009460 | 0.70 | HCRTR2 (0.34) | LMNANPC1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL7144062 | 0.69 | KMT2A (0.40) | NPC1RAB9A | |
| SCHEMBL7012737 | 0.68 | GABRP (0.45) | HTR6HCRTR1HCRTR2 | |
| SCHEMBL7013385 | 0.68 | NPY5R (0.38) | NPC1TSHRRAB9AP2RX3 | |
| SCHEMBL7004741 | 0.67 | HTR7 (0.34) | TSHR | |
| SCHEMBL7011132 | 0.67 | CYP1A2 (0.34) | LMNAHTR6TSHR | |
| SCHEMBL7009877 | 0.67 | HTR7 (0.36) | LMNAHTR6 | |
| SCHEMBL7151385 | 0.66 | NPY5R (0.38) | HTR6NPC1RAB9A | |
| SCHEMBL16860861 | 0.65 | NOTUM (0.36) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129089-A4 | SPIRO-INDOLINES AS Y5 RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1129089-A1 | SPIRO-INDOLINES AS Y5 RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027845-A1 | SPIRO-INDOLINES AS Y5 RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |