SCHEMBL7007280

SCHEMBL7007280

Cc1ccc2cccc(OCc3c(Cl)ccc(-n4cccc4C(N)C(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1

nearest known ligand 0.59

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7014752 0.87 BDKRB2 (0.63) BDKRB2
SCHEMBL7007182 0.86 BDKRB2 (0.54) BDKRB2
SCHEMBL7016569 0.86 BDKRB2 (0.60) BDKRB2
SCHEMBL7014258 0.86 BDKRB2 (0.73) BDKRB2
Hydrochloric Acid SCHEMBL7015839 0.86 BDKRB2 (0.74) BDKRB2
SCHEMBL7005518 0.85 BDKRB2 (0.57) BDKRB2
SCHEMBL7667827 0.85 BDKRB2 (0.49) BDKRB2
SCHEMBL7007285 0.85 BDKRB2 (0.78) BDKRB2
SCHEMBL7007288 0.85 BDKRB2 (0.78) BDKRB2
SCHEMBL7012859 0.84 BDKRB2 (0.61) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861243-B1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2003-11-12 EP disclosed
US-6344462-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-02-05 US disclosed
US-6100284-A ANTIALLERGENS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-08-08 US disclosed