Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009673 | 0.88 | KDM4E (0.40) | KDM4ESMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL7011711 | 0.81 | KDM4E (0.35) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7008607 | 0.79 | KDM4E (0.43) | KDM4ESMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8563133 | 0.72 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7007533 | 0.72 | GRIN2D (0.43) | SMN1; SMN2KMT2AALDH1A1MAPTGRIN2D | |
| SCHEMBL7009670 | 0.70 | GRIN2D (0.41) | SMN1; SMN2KMT2AHSD17B10MAPTGRIN2D | |
| SCHEMBL7011304 | 0.68 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL7013173 | 0.67 | TYMS (0.32) | ALDH1A1MAPT | |
| SCHEMBL7145066 | 0.64 | GRIN2D (0.52) | KDM4ESMN1; SMN2KMT2AALDH1A1GRIN2D | |
| SCHEMBL7014254 | 0.64 | MEN1 (0.43) | KDM4ESMN1; SMN2KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | claimed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | claimed |
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | disclosed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6015820-A | VIRICIDES; AIDS TREATMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2000-01-18 | — | — | US | disclosed |
| EP-0843663-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997005113-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1997-02-13 | — | — | WO | disclosed |