Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008563 | 0.94 | TP53 (0.47) | RORCTP53CNR1CNR2NPC1 | |
| Hydrochloric Acid SCHEMBL7012537 | 0.93 | TP53 (0.46) | RORCTP53CNR1CNR2NPC1 | |
| SCHEMBL7011016 | 0.92 | TP53 (0.44) | RORCTP53CNR1CNR2DRD2 | |
| Hydrochloric Acid SCHEMBL7014491 | 0.91 | TP53 (0.43) | RORCTP53CNR1CNR2DRD2 | |
| SCHEMBL7011216 | 0.90 | RORC (0.42) | RORCTP53CNR1CNR2DRD2 | |
| SCHEMBL7007952 | 0.89 | RORC (0.42) | RORCTP53CNR1CNR2DRD2 | |
| SCHEMBL7011281 | 0.89 | ROCK2 (0.44) | RORCCNR1CNR2ROCK2NPC1 | |
| SCHEMBL7008605 | 0.89 | RORC (0.42) | RORCTP53CNR1CNR2ROCK2 | |
| Hydrochloric Acid SCHEMBL7013455 | 0.88 | ROCK2 (0.44) | RORCCNR1CNR2ROCK2NPC1 | |
| Hydrochloric Acid SCHEMBL7008692 | 0.88 | RORC (0.41) | RORCTP53CNR1CNR2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |