Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012602 | 0.85 | MAPT (0.49) | BRAFRAF1TP53MAPTTHRB | |
| Hydrochloric Acid SCHEMBL7014137 | 0.84 | MAPT (0.49) | BRAFRAF1TP53MAPTTHRB | |
| SCHEMBL7007201 | 0.84 | MAPT (0.44) | BRAFRAF1TP53MAPTTHRB | |
| SCHEMBL7013060 | 0.83 | MAPT (0.49) | BRAFRAF1TP53MAPTTHRB | |
| SCHEMBL7945155 | 0.80 | BRAF (0.51) | BRAFRAF1 | |
| SCHEMBL7008283 | 0.79 | MAPT (0.51) | BRAFRAF1TP53MAPTTHRB | |
| SCHEMBL7011226 | 0.79 | MAPT (0.48) | BRAFRAF1TP53MAPTTHRB | |
| SCHEMBL7012290 | 0.74 | MAPT (0.51) | BRAFRAF1TP53MAPTTHRB | |
| SCHEMBL7009946 | 0.73 | NAMPT (0.52) | — | |
| Hydrochloric Acid SCHEMBL7008344 | 0.73 | NAMPT (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | claimed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |