Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955614 | 0.91 | BRAF (0.44) | BRAFRAF1ROCK2 | |
| SCHEMBL7945192 | 0.89 | HTR2A (0.42) | BRAFRAF1ROCK2CYP3A4KIT | |
| Hydrochloric Acid SCHEMBL8130753 | 0.89 | HTR2A (0.42) | BRAFRAF1ROCK2CYP3A4KIT | |
| SCHEMBL7953320 | 0.88 | KCNQ3 (0.56) | BRAFRAF1ROCK2CYP3A4 | |
| SCHEMBL7953516 | 0.87 | SMN1; SMN2 (0.44) | BRAFROCK2KIT | |
| SCHEMBL8136825 | 0.87 | KMT2A (0.46) | BRAFRAF1ROCK2CYP3A4KIT | |
| Hydrochloric Acid SCHEMBL7958472 | 0.86 | ROCK2 (0.42) | BRAFRAF1ROCK2CYP3A4KIT | |
| SCHEMBL7945228 | 0.86 | ABL1 (0.48) | BRAFKIT | |
| SCHEMBL7951826 | 0.86 | ROCK2 (0.59) | ROCK2CYP3A4 | |
| SCHEMBL7953978 | 0.86 | KMT2A (0.53) | ROCK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | claimed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |