Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 20/20 | 0.76 |
| ▸ | HTR1A | P08908 | 19/20 | 0.76 |
| ▸ | HTR1D | P28221 | 17/20 | 0.76 |
| ▸ | HTR1B | P28222 | 17/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | HTR1E | P28566 | 1/20 | 0.69 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30909241 | 1.00 | HTR1F (0.76) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7010256 | 0.87 | HTR1F (1.00) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7014281 | 0.86 | HTR1A (0.81) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7011619 | 0.86 | HTR1F (0.75) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7008481 | 0.84 | HTR1A (1.00) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7012219 | 0.83 | HTR1F (0.81) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7007762 | 0.83 | HTR1A (1.00) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7009522 | 0.83 | HTR1F (1.00) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL30909180 | 0.83 | HTR1F (1.00) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7008308 | 0.83 | HTR1F (0.80) | HTR1FHTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368355-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND THIAZOLOPYRIMIDINES | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | claimed |
| WO-2002072585-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND THIAZOLOPYRIMIDINES USED AS ANALGESICS | Grünenthal GmbH (DE) | 2002-09-19 | — | — | WO | claimed |
| EP-1368355-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND THIAZOLOPYRIMIDINES | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| EP-0842934-B1 | 5-HT1F agonists | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002072585-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND THIAZOLOPYRIMIDINES USED AS ANALGESICS | Grünenthal GmbH (DE) | 2002-09-19 | — | — | WO | disclosed |
| EP-1082958-A2 | 5-HT1F agonists in chronic pain | ELI LILLY AND COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| US-5998622-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5919936-A | 5-HT1F AGONIST INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5817671-A | ANTISEROTONIN AGENT; ANALGESICS; MIGRAINE THERAPY; COMPOUND CONTAINING PYRROLO(3,2-B)PYRIDINE RING | ELI LILLY AND COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0842934-A1 | 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |